Extra centrosomes and/or chromosomes prolong mitosis in human cells
- 11 May 2008
- journal article
- research article
- Published by Springer Nature in Nature Cell Biology
- Vol. 10 (6) , 748-751
- https://doi.org/10.1038/ncb1738
Abstract
Using laser microsurgery and cell fusion we have explored how additional centrosomes and/or chromosomes influence the duration of mitosis in human cells. We found that doubling the chromosome number added approximately 10 min to a 20 min division, whereas doubling the number of centrosomes added approximately 30 min more. Extra centrosomes and/or chromosomes prolong mitosis by delaying satisfaction of the spindle assembly checkpoint. Thus mitosis can be prolonged by non-genetic means and extra chromosomes and centrosomes probably contribute to the elevated mitotic index seen in many tumours.Keywords
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