Inhibition of neutrophil chemotaxis in methotrexate-treated rheumatoid arthritis patients
- 1 January 1988
- journal article
- conference paper
- Published by Springer Nature in Rheumatology International
- Vol. 8 (1) , 41-45
- https://doi.org/10.1007/bf00541349
Abstract
Polymorphonuclear cell (PMN) chemotaxis was assessed using the in vitro under agarose assay in ten rheumatoid arthritis patients prior to and following a single 10-mg dose of methotrexate (MTX). PMNs obtained from patients after MTX showed a decreased chemotactic migration response to both zymosan activated serum (PPP<0.99).Keywords
This publication has 23 references indexed in Scilit:
- Polyglutamation of methotrexate. Is methotrexate a prodrug?Journal of Clinical Investigation, 1985
- Comparison of low‐dose oral pulse methotrexate and placebo in the treatment of rheumatoid arthritis. A Controlled Clinical TrialArthritis & Rheumatism, 1985
- Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow.Journal of Clinical Investigation, 1985
- Characterisation of the under-agarose method for quantifying migration of highly purified human monocytesJournal of Immunological Methods, 1984
- EFFECTS OF METOTREXATE, AMPICILLIN AND GENTAMICIN ALONE AND IN COMBINATION ON THE IN VITRO LOCOMOTION ON HUMAN POLYMORPHONUCLEAR CELLS (PMN)Acta Pathologica Microbiologica Scandinavica Series C: Immunology, 1984
- Methotrexate inhibits polymorphonuclear leucocyte chemotaxis in psoriasisBritish Journal of Dermatology, 1983
- Effect of leukaemia therapy on neutrophil chemotaxis.Journal of Clinical Pathology, 1981
- The effect of methotrexate and hydroxyurea on neutrophil chemotaxisBritish Journal of Dermatology, 1980
- The anti‐inflammatory effect of some immunosuppressive agentsThe Journal of Pathology, 1969
- Increased Level of Dihydrofolic Reductase in Leucocytes of Patients Treated with AmethopterinNature, 1962