In-vitro activity of DR-3355, an optically active isomer of ofloxacin, against bacterial pathogens associated with travellers' diarrhoea
- 1 October 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 24 (4) , 547-549
- https://doi.org/10.1093/jac/24.4.547
Abstract
The in-vitro activity of DR-3355, the S-(—)-isomer of ofloxacin, was determined against bacterial pathogens associated with travellers' diarrhoea. DR-3355 was highly active against isolates of enteropathogenic Escherichia coli (MIC90 0·05 mg/l), Salmonella spp. (MIC90 0·10 mg/l), Shigella spp. (MIC90 0·10 mg/l), Campylobacter jejuni (MIC90 0·39 mg/l) and Vibrio parahaemolyticus (MIC90 0·39 mg/l). The activity of DR-3355 against these bacteria was generally two- to eight-fold greater than that of ofloxacin and equal to, or only two-fold less than, that of ciprofloxacin with the exception of isolates of C. jejuni, which were two-fold less susceptible to ciprofloxacin than to DR-3355.Keywords
This publication has 1 reference indexed in Scilit:
- In vitro activity of DR-3355, an optically active ofloxacinAntimicrobial Agents and Chemotherapy, 1988