Rates and Extents of Antifungal Activities of Amphotericin B, Flucytosine, Fluconazole, and Voriconazole against Candida lusitaniae Determined by Microdilution, Etest, and Time-Kill Methods
Open Access
- 1 February 2002
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (2) , 578-581
- https://doi.org/10.1128/aac.46.2.578-581.2002
Abstract
Amphotericin B, flucytosine, fluconazole, and voriconazole alone and in combination were evaluated against isolates of Candida lusitaniae . MICs were determined by broth microdilution and Etest, and time-kill studies were conducted. Amphotericin B resulted in fungicidal activity against most isolates, whereas fluconazole, voriconazole, and flucytosine produced primarily fungistatic activities. The addition of flucytosine to amphotericin B resulted in a faster rate and greater extent of kill for isolates for which the MICs of amphotericin B were elevated.Keywords
This publication has 10 references indexed in Scilit:
- In vitro interaction of fluconazole and amphotericin B administered sequentially against Candida albicans: effect of concentration and exposure timeDiagnostic Microbiology and Infectious Disease, 1998
- Assessment of Antifungal Activities of Fluconazole and Amphotericin B Administered Alone and in Combination against Candida albicans by Using a Dynamic In Vitro Mycotic Infection ModelAntimicrobial Agents and Chemotherapy, 1998
- Therapeutic drug monitoring of systemic antifungal therapyJournal of Antimicrobial Chemotherapy, 1997
- Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicansAntimicrobial Agents and Chemotherapy, 1997
- Successful treatment of cerebral aspergillosis with a novel triazole (voriconazole) in a patient with acute leukaemiaBritish Journal of Haematology, 1997
- In-vitro susceptibility pattern of Candida lusitaniae and evaluation of the Etest methodJournal of Antimicrobial Chemotherapy, 1997
- Comparison of Etest and National Committee for Clinical Laboratory Standards broth macrodilution method for antifungal susceptibility testing: enhanced ability to detect amphotericin B-resistant Candida isolatesAntimicrobial Agents and Chemotherapy, 1995
- Detection of amphotericin B-resistant Candida isolates in a broth-based systemAntimicrobial Agents and Chemotherapy, 1995
- Strain delineation and antifungal susceptibilities of epidemiologically related and unrelated isolates of Candida lusitaniaeDiagnostic Microbiology and Infectious Disease, 1994
- Mycoses Caused by Candida lusitaniaeClinical Infectious Diseases, 1987