In vivo and in vitro studies of inhibitory effects of restorative dental materials on salivary esterases

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Abstract
The influence of 18 dental materials on the activity of esterases isolated, from human whole saliva has been studied. Eugenol on its own was a strong competitive inhibitor of the esterases II‐2a (Ki = 3.3/10−5 M) and II‐2b (Ki = 4.7/10−6 M). Except for Luralite® all the materials that contained eugenol as one of the components (IRM®, Nobetec® and Opotow®) were noncompetitive inhibitors. Additional in vitro inhibitors were: Adaptic®, Aspa®, Coe‐pack® and the amalgam ANA 68®. Treatment with Nobetec packs in vivo resulted in a decrease in the esterase activity of whole saliva.