Toxicity of Gold Nanoparticles Functionalized with Cationic and Anionic Side Chains
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- 5 June 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Bioconjugate Chemistry
- Vol. 15 (4) , 897-900
- https://doi.org/10.1021/bc049951i
Abstract
The structure and properties of gold nanoparticles make them useful for a wide array of biological application. Toxicity, however, has been observed at high concentrations using these systems. MTT, hemolysis, and bacterial viability assays were used to explore differential toxicity among the cell types used, using 2 nm core particles. These studies show that cationic particles are moderately toxic, whereas anionic particles are quite nontoxic. Concentration-dependent lysis mediated by initial electrostatic binding was observed in dye release studies using lipid vesicles, providing the probable mechanism for observed toxicity with the cationic MMPCs.Keywords
This publication has 13 references indexed in Scilit:
- Designing peptide receptor agonists and antagonistsNature Reviews Drug Discovery, 2002
- Nucleic-acid therapeutics: basic principles and recent applicationsNature Reviews Drug Discovery, 2002
- Mimicry of Host-Defense Peptides by Unnatural Oligomers: Antimicrobial β-PeptidesJournal of the American Chemical Society, 2002
- Moving smaller in drug discovery and deliveryNature Reviews Drug Discovery, 2002
- Melittin Enables Efficient Vesicular Escape and Enhanced Nuclear Access of Nonviral Gene Delivery VectorsJournal of Biological Chemistry, 2001
- Oligonucleotide Adsorption to Gold Nanoparticles: A Surface-Enhanced Raman Spectroscopy Study of Intrinsically Bent DNAThe Journal of Physical Chemistry B, 2001
- Preparation and Properties of Vesicles Formed from Phospholipid Analogues of N-(Phosphonoacetyl)-L-aspartate (PALA) by Sonication or Extrusion: Transition Temperature, Particle Size, Glucose Entrapment, and 31P NMRLangmuir, 2001
- Quantitative and Reversible Lectin-Induced Association of Gold Nanoparticles Modified with α-Lactosyl-ω-mercapto-poly(ethylene glycol)Journal of the American Chemical Society, 2001
- Vesicle-Forming Properties of New Phospholipid Analogues Derived from N-Phosphonoacetyl-l-aspartate (PALA): Particle Features and Morphology in Relation with Alkyl Chain LengthsLangmuir, 2001
- Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase by a Reactive Metabolite of Acetaminophen and Mass Spectral Characterization of an Arylated Active Site PeptideChemical Research in Toxicology, 1997