SYNAPTOPHYSIN – AN IMMUNO‐HISTOCHEMICAL MARKER FOR CHILDHOOD NEUROBLASTOMA
- 1 July 1987
- journal article
- research article
- Published by Wiley in Acta Pathologica Microbiologica Scandinavica Series A :Pathology
- Vol. 95A (1-6) , 167-170
- https://doi.org/10.1111/j.1699-0463.1987.tb00026_95a.x
Abstract
Synaptophysin, an integral membrane glycoprotein of presynaptic vesicles, was tested as an immuno-histochemical marker for childhood neuroblastoma. Synaptophysin immuno-reactivity was found in all neuroblastomas (6/6), but not in the other small round-cell tumors to be considered in its differential diagnosis. Thus, rhabdomyosarcomas (05), lymphomas (0/4), or Ewing''s sarcomas (02) were negative for synaptophysin. The results suggest that synaptophysin is a useful marker for neuroblastoma, and it should belong to the marker panel used for the differential diagnosis of small round-cell tumors of childhood.Keywords
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