Some Effects of Age on the Biochemistry of Acute Inflammation

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Abstract
Biochemical changes were studied during an experimental inflammatory response in the palates of 12-month-old rats. In non-inflamed palate tissue, these rats have reduced concentrations of water, glycogen, hexosamine, tyrosine, inorganic phosphorus, acid-soluble organic phosphorus and DNA, the same concentration of RNA, and possibly a slightly increased concentration of hydroxyproline compared to 3-month-old animals. The major chemical differences in the inflammatory response of 12-month-old rats as compared with 3-month-old rats were an increase in the height of the glycogen maximum, a decrease in the DNA and acid-soluble organic phosphorus maxima, and an alteration in the terminal portions of the curves for water, glycogen, hydroxyproline, hexosamine and non-protein nitrogen. Curves for total nitrogen, tyrosine and RNA were unaffected.

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