Effects of physical training on metabolism of connective tissues in young mice

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Abstract
The effects of physical training on the metabolism of collagen, Ca and glycosaminoglycans in various connective tissues were studied in male NMRI mice. The mice to be trained and their controls were about 3 wk old (I) and 8 wk old (II) at the commencement of training. The training was performed on a 5.degree. inclined treadmill 5 days a wk for 4 wk in I and for 3 wk in II. The daily exercise time was progressively increased from 20 min in the 1st wk up to 80 min in the 3rd wk. The incorporation of 3H-proline to collagen hydroxyproline was increased by training in long bones, skeletal muscle and Achilles tendon; the incorporation of 35S-sulfate into glycosaminoglycans of bones was lower for the trained compared to the control mice. The differences between the 2 groups in the incorporation of 45Ca were negligible. . Metabolism of collagen is accelerated by physical training in several connective tissues in young rapidly growing mice; metabolism of glycosaminoglycans remains unaffected or is even retarded.