RETINAL-PIGMENT EPITHELIUM - INTERRELATIONS OF ENDOPLASMIC-RETICULUM AND MELANOLYSOSOMES IN THE BLACK MOUSE AND ITS BEIGE MUTANT

  • 1 January 1979
    • journal article
    • research article
    • Vol. 40  (2) , 155-165
Abstract
By cytochemistry (acid phosphatase and tyrosinase activities) GERL [golgi-endoreticular-lysosome], a specialized hydrolase-rich region of endoplasmic reticulum (ER), can be visualized in the cells of the mouse retinal pigment epithelium. Previously catalase cytochemistry permitted identification of microperoxisomes, with numerous continuities to the ER. Extensive continuities of the ER to pigment granules in various stages of maturation revealed. When the pigment granules in various stages of maturation were revealed. When the pigment granules ("melanolysomes") 1st appear they consist of electron-opaque grains within dilated areas of the ER. As the dilations enlarge, fine fibrils appear in the ER cisternae. Thicker fibers develop from the fibrils; these fibers are generally obscured when melanin deposition occurs. At all stages, the melanolysosomes appear to be connected to the ER.

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