Biochemical basis of heart function. XII. Sodium-potassium stimulated adenosine triphosphatase activity in the perfused rat heart made to fail by substrate-lack
- 1 March 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 8 (2) , 227-236
- https://doi.org/10.1093/cvr/8.2.227
Abstract
The activity of Na+−K+ stimulated ATPase obtained from the failing rat heart due to substrate-lack was lower than that in heart perfused with medium containing glucose. Depressed contractile force and Na+−K+ ATPase activity of the hearts perfused with substrate-free medium for 1 hr were reversible on further perfusion of the hearts with medium containing glucose. The results indicate the role of exogenous substrate in the maintenance of Na+−K+ ATPase activity in the myocardium and lend further support to our contention concerning membrane abnormality in heart failure.Keywords
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