Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons
- 7 August 2005
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 8 (9) , 1142-1144
- https://doi.org/10.1038/nn1517
Abstract
Ablation of preBötzinger complex (preBötC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBötC neurons and could underlie death during sleep in these populations.Keywords
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