Mapping and characterization of the DQ subregion of the ovine MHC
- 1 August 1994
- journal article
- Published by Wiley in Animal Genetics
- Vol. 25 (4) , 243-249
- https://doi.org/10.1111/j.1365-2052.1994.tb00200.x
Abstract
A map of the ovine MHC class II DQ subregion has been constructed from overlapping cosmid clones. This region consists of two loci linked on a linear tract of 130 kb DNA. Each locus consists of a DQA and a DQB gene in a tail-to-tail orientation. The genes in each locus are transcribed but only those designated DQ1 express class II molecules at the surface of mouse L cells following DNA-mediated gene transfection. The DQA1 and DQB1 genes are separated by 11 kb while the DQA2 and B2 genes are 25 kb apart. The loci are separated by 22 kb.Keywords
This publication has 23 references indexed in Scilit:
- Isolation, characterization and evolution of ovine major histocompatibility complex class II DRA and DQA genesAnimal Genetics, 1993
- Map of the human MHCImmunology Today, 1993
- The Biochemistry and Cell Biology of Antigen Processing and PresentationAnnual Review of Immunology, 1993
- Expression and characterization of ovine major histocompatibility complex class II (OLA‐DR) genesAnimal Genetics, 1992
- CLUSTAL V: improved software for multiple sequence alignmentBioinformatics, 1992
- Class II major histocompatibility complex genes of the sheepAnimal Genetics, 1991
- Chromosome banding and gene localizations support extensive conservation of chromosome structure between cattle and sheepCytogenetic and Genome Research, 1991
- HUMAN CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX GENES AND PROTEINSAnnual Review of Biochemistry, 1988
- Characterization of Eukaryotic Transcriptional Control Signals by Assay of Herpes Simplex Virus Type 1 Thymidine KinaseJournal of General Virology, 1983
- Clusters of genes encoding mouse transplantation antigensCell, 1982