Drug-Induced Tolerance for Skin Allografts across the H-2 Barrier in Adult Mice
- 18 May 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 156 (3777) , 951-954
- https://doi.org/10.1126/science.156.3777.951
Abstract
Mice treated with methylhydrazine derivatives for 3 to 4 weeks before the transplantation showed markedly prolonged survival times for allogeneic skin grafts differing at the H-2 histocompatibility locus. Presumably permanent tolerance was induced in about 20 to 30 percent of the mice when the drug treatment was combined with a single injection of additional donor antigen. The tolerance persists without further drug treatment and is specific for donor tissue.This publication has 11 references indexed in Scilit:
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