Site selectivity in self-catalysed functionalization of helical polypeptide structures
- 1 January 1997
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 3,p. 397-398
- https://doi.org/10.1039/a605776d
Abstract
Histidine side chains in helical structures catalyse the acylation of flanking lysine, ornithine and 1,3-diaminobutyric acid residues provided they are in positions i - 3 and i + 4, but not in positions i - 4, i - 1, i + 2, i + 3, relative to a histidine in position i, in a novel site-selective functionalization reaction that enhances the potential of polypeptide and protein design.Keywords
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