Dihydromonacolin L and monacolin X. new metabolites those inhibit cholesterol biosynthesis.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (3) , 321-327
- https://doi.org/10.7164/antibiotics.38.321
Abstract
Dihydromonacolin L and monacolin X, which are structurally related to monacolin K, a potent inhibitor of cholesterol biosynthesis, were isolated from cultures of a mutant of Monascus ruber. The structures of these 2 metabolites were determined by a combination of physical techniques. Data for dihydromonacolin L and monacolin X as inhibitors of hydroxymethylglutaryl-CoA reductase and sterol biosynthesis in vitro are also given.This publication has 3 references indexed in Scilit:
- Dihydromevinolin,a potent hypocholesterolemic metabolite produced by Aspergillus terreus.The Journal of Antibiotics, 1981
- Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.Proceedings of the National Academy of Sciences, 1980
- INHIBITION OF INVITRO CHOLESTEROL-SYNTHESIS BY FATTY-ACIDS1977