EFFECT OF GROWTH HORMONE AND ITS COMBINATION WITH ESTRADIOL-17β ON THE UTERUS OF HYPOPHYSECTOMIZED AND HYPOPHYSECTOMIZED-OVARIECTOMIZED RATS

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Abstract
Growth hormone (somatotropin) induced an increase in uterine weight in both hypophysectomized and hypophysectomized-ovariectomized rats. This hormone exerted a direct effect on the uterus, as well as an indirect one through the ovary. No other pituitary gonadotropins (e.g., FSH, ICSH and lactogenic hormone) when injected singly increased significantly the uterine weight in hypophysectomized rats, but when growth hormone was injected with ICSH the uterine weight was greater than when growth hormone was injected alone. Growth hormone exerted a synergistic effect with estradiol-17[beta] on the uterus of hypophysectomized and hypophysectomized-ovariectomized rats. These data furnish further evidence that somatotropin functions not only as a growth hormone but also as a biological synergist.