Iron Absorption after Renal Transplantation

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Abstract
Gastrointestinal Fe absorption was measured by means of whole body counting in 13 patients after renal allotransplantation. Whole body retention 14 days after oral administration of 10 .mu.Ci 59Fe together with a carrier dose of 9.9 mg Fe2+ was used as an expression of absorption. The percentage incorporation in the total erythrocyte mass of administered 59Fe (erythrocyte incorporation) and absorbed 59Fe (red cell utilization) was estimated as well. Geometric mean Fe absorption was 12.4 .+-. 2.5 (SD)% and geometric mean erythrocyte incorporation 11.1 .+-. 3.0 (SD)% while arithmetic mean red cell utilization was 95.6 .+-. 8.6 standard error of the mean %. None of these parameters differed significantly from those obtained in normal subjects (P > 0.2, P > 0.1, P > 0.3, respectively). Fe absorption and erythrocyte incorporation in renal transplanted patients did not differ significantly from the values measured in non-dialysed and dialysed patients with chronic renal failure (P > 0.01). The correlation between Fe absorption and erythrocyte incorporation was highly significant (r = 0.96, P < 0.001).

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