Expression of components of the IGF signalling system in childhood acute lymphoblastic leukaemia
- 1 February 2002
- journal article
- research article
- Published by BMJ in Molecular Pathology
- Vol. 55 (1) , 40-45
- https://doi.org/10.1136/mp.55.1.40
Abstract
Background: Alterations in the insulin-like growth factor (IGF) system have been reported for different tumours. They are of particular interest in the search for new prognostic and therapeutic approaches in cancer. In childhood acute lymphoblastic leukaemia (ALL) the amount of “tumour mass” at diagnosis can exceed 1 kg. To understand the endocrine, paracrine, and autocrine potential of the malignant transformed progenitor cells, the ability of these cells to express components of the IGF system needs to be investigated.Keywords
This publication has 44 references indexed in Scilit:
- The modular architecture of a new family of growth regulators related to connective tissue growth factorPublished by Wiley ,2001
- Neuroblastoma and insulin-like growth factor systemEuropean Journal of Pediatrics, 1997
- Serum levels of insulin-like growth factor-I,-II and insulin-like growth factor binding proteins-2 and-3 in children with acute lymphoblastic leukaemiaEuropean Journal of Pediatrics, 1996
- Induction of the growth inhibitor IGF-binding protein 3 by p53Nature, 1995
- Prognostic Significance of Insulin-like Growth Factor-Binding Protein Expression in Axillary Lymph Node-Negative Breast CancerJNCI Journal of the National Cancer Institute, 1994
- Insulin-like growth factor (IGF)-I, -II and IGF binding protein-2 (IGFBP-2) in the plasma of children with Wilms' tumourEuropean Journal Of Cancer, 1993
- Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.The Journal of cell biology, 1991
- The induction of a specific protease for insulin-like growth factor binding protein-3 in the circulation during severe illnessJournal of Endocrinology, 1991
- Insulinlike Growth Factors in Human MalignancyCancer Investigation, 1991
- Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cellsExperimental Cell Research, 1982