Diversifying microbial natural products for drug discovery
- 28 June 2003
- journal article
- review article
- Published by Springer Nature in Applied Microbiology and Biotechnology
- Vol. 62 (5-6) , 446-458
- https://doi.org/10.1007/s00253-003-1381-9
Abstract
Historically, nature has provided the source for the majority of the drugs in use today. More than 20,000 microbial secondary metabolites have been described, but only a small percentage of these have been carried forward as natural product drugs. Natural products are in tough competition with large chemical libraries and with combinatorial chemistries. Hence, each step of a natural product program has to be more efficient than ever, starting from the collection of environmental samples and the selection of strains, to metabolic expression, genetic exploitation, sample preparation and chemical dereplication. This review will focus on approaches for diversifying microbial natural product strains and extract libraries, while decreasing genetic and chemical redundancy.Keywords
This publication has 30 references indexed in Scilit:
- A genomics-guided approach for discovering and expressing cryptic metabolic pathwaysNature Biotechnology, 2003
- Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strainsNature Biotechnology, 2003
- Characterisation, genome size and genetic manipulation of the myxobacterium Sorangium cellulosum So ce56Archiv für Mikrobiologie, 2002
- High-Throughput Analysis of Natural Product Compound Libraries by Parallel LC−MS Evaporative Light Scattering DetectionAnalytical Chemistry, 2002
- High-Throughput Method for the Production and Analysis of Large Natural Product Libraries for Drug DiscoveryAnalytical Chemistry, 2002
- Drugs from the seas - current status and microbiological implicationsApplied Microbiology and Biotechnology, 2002
- Decipinin A and Decipienolides A and B: New Bioactive Metabolites from the Coprophilous Fungus Podospora decipiensJournal of Natural Products, 2002
- Development of a System To Evaluate Compound Identity, Purity, and Concentration in a Single Experiment and Its Application in Quality Assessment of Combinatorial Libraries and Screening HitsJournal of Combinatorial Chemistry, 2002
- Reactivity of Mono-Meso-Substituted Iron(II) Octaethylporphyrin Complexes with Hydrogen Peroxide in the Absence of Dioxygen. Evidence for Nucleophilic Attack on the HemeJournal of the American Chemical Society, 2001
- Endophytes: a rich source of functional metabolites (1987 to 2000)Natural Product Reports, 2001