Alterations in Cardiovascular Responses of the Dog Following Rauwiloid. An Alkaloidal Extract of Rauwolfia serpentina

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Abstract
Rauwiloid, an alkaloidal mixture representing the total activity of the root of Rauwolfia serpentina, Benth., was admn. orally for 5 days to 15 dogs at a dose of 0.5 mg./kg./day. The following observations (compared to 15 control animals) were obtained on the 6th day: (l)Mean arterial pressure and heart rate decreased significantly; (?* sedation in 11; (3) increase of the pressor response to epinephrine; (4) enhancement of the hypotensive and cardio.accelerator effecte of isopropylnorepinephrine (Isuprel); (5) reversal of the blood pressure rise generally evoked by hypoxia; (6) decrease in the carotid sinus pressor reflex; (7) blockade of the primary blood pressure rise elicited by faradization of the afferent vagus the secondary rise being essentially unaltered; (8) no change in the hypotensive responses to acetyl-choline, histamine, and efferent vagal faradization. It remains to be shown whether this depression of reflex pressor responses (carotid body, carotid sinus, vagal) is causal to the hypotension.

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