Effect of Hydrazine on Protein Content of Various Tissues in the Rat

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Abstract
Summary Hydrazine treatment caused an enlargement in livers of rats which appeared to be associated with increased protein content of that organ. This rise in liver protein content was correlated with an increased liver RNA. Similar changes in protein and RNA were not observed in the kidney and gonads. The hydrazine-induced elevation in both liver protein and RNA content is consistent with a stimulation of protein biosynthesis. Furthermore, the effect of hydrazine on liver protein appears to be primarily metabolic rather than nutritional.