An open assay model to induce subclinical non‐erythematous irritation

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Abstract
To avoid the acute irritation and dryness that a single occlusive surfactant application (24‐h patch test) may cause, and to approximate clinical use, an open application model was chosen to define subclinical non‐erythematous irritation in the stratum corneum. This human test combined a supervised washing at the laboratory with at‐home use of the test products by the subjects. Effects of washing with the surfactants on the dorsal hand and volar forearm were compared. The results demonstrated that this situational use model permits the exploration of subclinical surfactant‐induced irritation. The forearm appeared to be more discriminative as compared to the dorsal hand. Squamometry proved to be a sensitive, complementary assessment method for detecting surfactant‐induced subclinical skin surface alterations and for differentiating surfactant effects in this open assay.

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