In-vitro cytotoxic activity of cross-linked protein microcapsules

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Abstract
Microcapsules (5-100 μm) were prepared through interfacial cross-linking of various proteins (human serum albumin, lysozyme, haemoglobin, casein, pepsin) with glutaraldehyde or terephthaloylchloride. Surprisingly they all snowed an inhibitory effect on cultured cells in a concentration range of 100 μg ml−1 to 10 mg ml−1. This effect seemed non-specific, reversible and to depend on contact with the cell plasma membrane. The electric charges of microcapsules could be involved in the inhibition phenomenon.