HIGH-STABILITY HYBRIDS PRODUCING MONOCLONAL-ANTIBODIES AGAINST HUMAN C-REACTIVE PROTEIN

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 40  (3) , 279-288
Abstract
High stability hybrids producing monoclonal antibodies against human C-reactive protein were raised and selected. Monoclonal antibodies can be produced in large enough quantities through this method to allow for the design and use of quantitative C-reactive protein determination on a clinical scale. The hybrids were grown and frozen before cloning to assure stability. The hybrids were selected from those producing high titers in mouse ascite induction. Two monoclonal antibodies of high stability and great potential for large scale production were developed in this manner. Production on a large scale of these monoclonal antibodies against human C-reactive protein can be useful both in clinical quantification and in physiological studies concerning its still unknown in vivo function.