Sodium Chloride Suppression of Renin Release in the Unanesthetized Rat

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Abstract
Previous studies showed that increased NaCl in drinking water failed to suppress serum renin activity (SRA) in the ether-anesthetized rat. In the absence of anesthesia, NaCl decreased SRA by 76% and serum aldosterone by 72%. Deoxycorticosterone acetate, when given alone, produced similar results but was more effective in reducing SRA (96%) when combined with NaCl. If light ether anesthesia was administered prior to blood collection, there was a 10-fold increase in SRA and the effects of NaCl were blocked. In the absence of anesthesia, the renin-angiotensin-aldosterone system of the rat responds, as in other species, to a Na load.

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