THE EFFECT OF THEOPHYLLINE ON THE LOWER ESOPHAGEAL SPHINCTER PRESSURE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 45  (4) , 238-241
Abstract
The effects of theophylline on lower esophageal sphincter pressure (LESP) were studied in 4 normal volunteers and 6 asthmatics with symptoms of gastroesophageal reflux (GER). Manometric evaluations of LESP were obtained before and after an i.v. dose of aminophylline. All subjects had therapeutic theophylline levels at the time of the 2nd measurement of LESP. A significant decrease in LESP occurred in normal and asthmatic volunteers.