Three New Pseudodistomins, Piperidine Alkaloids from the Ascidian Pseudodistoma megalarva

1 October 1997

journal article
research article
Published by American Chemical Society (ACS) in Journal of Natural Products

Vol. 60 (10) , 986-990
https://doi.org/10.1021/np9701438

Abstract

Bioassay-guided fractionation of the MeOH−CH₂Cl₂ extract of the Micronesian ascidian Pseudodistoma megalarva yielded three new piperidine alkaloids, pseudodistomins D−F (3−5) and the previously reported pseudodistomins B and C (1 and 2). The structure and stereochemistry of these compounds were established by interpretation of spectral data. Pseudodistomins B−F were found to be active in a cell-based assay for DNA damage induction, but the activity was due to an alternative mechanism.

Keywords

This publication has 3 references indexed in Scilit:

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