In vivo gene therapy for colon cancer using adenovirus-mediated, transfer of the fusion gene cytosine deaminase and uracil phosphoribosyltransferase
- 1 October 2001
- journal article
- research article
- Published by Springer Nature in Gene Therapy
- Vol. 8 (20) , 1547-1554
- https://doi.org/10.1038/sj.gt.3301557
Abstract
At the forefront of medicine, Gene Therapy brings you the latest research into genetic and cell-based technologies to treat disease. It also publishes Progress & Prospects reviews and News and Commentary articles, which highlight the cutting edge of the field.Keywords
This publication has 12 references indexed in Scilit:
- A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancerNature Medicine, 2000
- Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trialPublished by Elsevier ,2000
- Cytosine Deaminase/5-Fluorocytosine-Based Vaccination Against Liver Tumors: Evidence of Distant Bystander EffectJNCI Journal of the National Cancer Institute, 1999
- Concomitant expression ofE. colicytosine deaminase and uracil phosphoribosyltransferase improves the cytotoxicity of 5-fluorocytosineFEMS Microbiology Letters, 1998
- Phase I Study of Direct Administration of a Replication Deficient Adenovirus Vector Containing theE. coliCytosine Deaminase Gene to Metastatic Colon Carcinoma of the Liver in Association with the Oral Administration of the Pro-Drug 5-Fluorocytosine. The New York Hospital-Cornell Medical Center, New York, NYHuman Gene Therapy, 1997
- Tumor-specific gene expression in carcinoembryonic antigen--producing gastric cancer cells using adenovirus vectorsGastroenterology, 1996
- Characterization of 911: A New Helper Cell Line for the Titration and Propagation of Early Region 1-Deleted Adenoviral VectorsHuman Gene Therapy, 1996
- In VivoAdenovirus-Mediated Gene Transfer of theEscherichia coliCytosine Deaminase Gene to Human Colon Carcinoma-Derived Tumors Induces Chemosensitivity to 5-FluorocytosineHuman Gene Therapy, 1995
- Surgical treatment of liver metastases in patients with colorectal cancerCancer, 1993
- Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system.Proceedings of the National Academy of Sciences, 1992