Receptor‐like Activity of a Monoclonal Anti‐Idiotypic Antibody against an Anti Acetylcholine Receptor Antibody
- 1 May 1984
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 19 (5) , 485-489
- https://doi.org/10.1111/j.1365-3083.1984.tb00958.x
Abstract
A monoclonal anti-idiotypic antibody against an anti-acctylcholine receptor antibody from a patient with myasthenia gravis was shown to bind the cholinergie ligand α-bungarotoxin. This binding could be inhibited by other cholinergic ligands. boih antagonists und agonists. The anti-idioiype was also able to elicit the production of anti-receptor antibodies in mice Thus, the anti-idiotype had functional properties similar to those of the original antigen, the acetylcholine receptor.Keywords
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