INFLUENCE OF A SYNTHETIC PROSTAGLANDIN ANALOG ON PANCREATIC-SECRETION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 79  (5) , 509-514
Abstract
Effects of a synthetic prostaglandin analog-16, 16-dimethyl prostaglandin E2, methyl ester (16-diMe-PGE2), on pancreatic secretion were evaluated in 7 dogs with chronic duodenal fistulas. Graded doses of 16-diMe-PGE2 were administered i.v. (0.1, 0.3, 0.5 and 1.0 .mu.g/kg, intraduodenally or intragastrically (15, 30, 50, 100 .mu.g/kg) with the pancreas in the resting state or in response to secretin and secretin with cholecystokinin-pancreozymin. Profound and prolonged inhibition of volume and the bicarbonate concentration of secretions occurred in the resting and stimulated gland. ED50 was 0.31 .mu.g/kg i.v. (1/75 the ED50 for PGE1) and 25 .mu.g/kg intraduodenally. As with PGE1, stimulation of enzymes occurred, even with doses that were subthreshold for inhibition of volume and HCO3. Like PGE1, 16-diMe-PGE2 has a dual action on the intact canine pancreas (stimulation of enzymes and inhibition of volume and electrolytes), but is much more potent, has a prolonged action and is active intraduodenally and intragastrically. Nonsteroid inhibitors of endogenous prostaglandin synthesis did not alter these effects.

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