Precocious Menstruation in Hypothyroidism

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Abstract
A short description is given of a girl with hypothyroidism, precocious menstruation and metropathia hemorrhagica. After thyroid therapy menstruation stopped immediately; at the age of 14 normal puberty occurred. Findings in the literature of five other patients with the same syndrome are summarized. The explanation offered by van Wyk and Grumbach is mentioned hypothyroidism results in stimulation of thyrotropic activity with overlap to gonadotropic activity. Though this theory has not yet been proved conclusively, the characteristics of the syndrome fit in well with it.