Thiourea Reverses Cross-Links and Restores Biological Activity in DNA Treated with Dichlorodiaminoplatinum(II)
- 13 April 1979
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 204 (4389) , 181-183
- https://doi.org/10.1126/science.571145
Abstract
Cis and trans dichlorodiaminoplatinum (II) compounds bind to DNA and form DNA cross-links, which are usually considered to be irreversible. Thiourea can reverse these cross-links without any apparent breakdown of the DNA. In addition, cis- and trans-Pt (II) treatment of lambda decreases its transfectivity. After suitable incubation with thiourea, full transfectivity of Pt(II)-treated lambda DNA can be restored.Keywords
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