Contact sensitivity to quinidine sulfate from occupational exposure

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Abstract
Three pharmaceutical industry workers exposed to the drug quinidine sulfate became sensitized after short exposure times (2-3 mo.). They were patch test positive to quinidine in different vehicles, but negative to the diastereoisomer quinine. Guinea pig maximization tests demonstrated quinidine and quinine to be grade V allergens according to the classification of Magnusson and Kligman. When challenged for cross-reactivity, the animals sensitive to quinine did not react to quinidine. Among the quinidine-sensitive guinea pigs, 3 of 20 (P > 0.05) reacted when challenged with quinine.