EFFECTS OF VINBLASTINE AND COLCHICINE ON OXYTOCIN LEVELS OF THE POSTERIOR PITUITARY OF THE RAT AFTER SALINE TREATMENT

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Abstract
Mitotic inhibitors injected into the subarachnoid space retard the transport of incorporated amino acids in the hypothalamo-hypophysial system of rats (Norström, Hansson & Sjöstrand, 1971), and Boudier & Detieux (1971) found that the effect of intracisternal colchicine on the recovery from dehydration of neurosecretory material at the light and electron microscopic level retarded the accumulation of material in the neurohypophysis without affecting the microtubules. In preliminary experiments, attempts to produce effects on the levels of oxytocin stored in the posterior pituitary by injections of vinblastine and colchicine produced equivocal results, probably due to the relatively low rates of synthesis and release in healthy animals compared with the large amounts of hormones stored. It was decided, therefore, to lower the levels of stored hormone by allowing adult male Wistar rats (180–200 g) access ad libitum to 2% NaCl solution in place of water for 5 days (Jones & Pickering, 1969) and

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