The Availability for Recognition of Normal H‐2 Antigens by Cytotoxic T Lymphocytes on a Rauscher‐Virus‐transformed Cell, RBL‐5A
- 1 October 1979
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 10 (4) , 353-358
- https://doi.org/10.1111/j.1365-3083.1979.tb01363.x
Abstract
The availability for recognition of cell surface H‐2Db antigenic determinants on RBL‐5A cells in comparison to normal C57BL/6 cells was investigated by an in vitro immunological assay. No differences in the immunological recognition of the H‐2Db antigens on RBL‐5A cells compared to normal C57BL/6 cells were detected. This assay system, however, readily detected changes in the H‐2Kb determinant profile an target cells from the C37BL/6 H‐2Kb region mutant strains H(z1) and H(z170) when compared to normal C57BL/6 mice. The result obtained with RBL‐5A target cells therefore suggests that Rauscher murine leukaemia virus transformation does not induce, either genotypically or phenotypically, an immunologically recognizable alteration of the H‐2Db antigen profile on this cell.This publication has 28 references indexed in Scilit:
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