CONCOMITANT DEVELOPMENT OF [3H]‐DOPAMINE AND [3H]‐5‐HYDROXYTRYPTAMINE UPTAKE SYSTEMS IN RAT BRAIN REGIONS

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Abstract
1 Synaptosomal uptake mechanisms of 5-hydroxytryptamine and dopamine were examined in cerebral cortex, corpus striatum and midbrain plus brainstem of developing rats. 2 In all regions, there was generally a parallel biphasic development of both uptake systems; the most rapid increases occurred in the first two weeks postpartum, followed by a slower rate of increase. 3 Kinetic studies with dopamine indicated that the maturation involved increases in maximal uptake without a change in the substrate Km, suggesting that there is a change in the number of terminals but not in the uptake system per se.