Pharmacokinetic interaction of disulfiram and antidepressants
- 1 November 1985
- journal article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 142 (11) , 1373-1374
- https://doi.org/10.1176/ajp.142.11.1373
Abstract
Intravenous imipramine and desipramine were administered to two detoxified alcoholics before and during disulfiram treatment. Tricyclic pharmacokinetic parameters, determined from plasma samples over 48 hours, indicated decreased total body clearance, increased elimination half-life, and higher peak plasma levels during disulfiram treatment.Keywords
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