In Vivo Localization of Insulin Binding to Cells of the Rat Pancreas
- 1 April 1984
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 175 (4) , 497-502
- https://doi.org/10.3181/00379727-175-41827
Abstract
The uptake of 125I-insulin by rat pancreas was studied in vivo. Following fixation and light microscope autoradiography, saturable uptake of 125I-insulin was quantitatively demonstrated on acinar and duct cells but not on blood vessels and islets of Langerhans. EM revealed the localization of 125I-insulin to the basolateral cell membranes of acinar and duct cells.This publication has 3 references indexed in Scilit:
- Insulin action in pancreatic acini from streptozotocin-treated rats. III. Electron microscope autoradiography of 125I-insulinAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 1981
- Insulin receptors in isolated mouse pancreatic aciniBiochemical and Biophysical Research Communications, 1978
- Binding of insulin to isolated nuclei.Proceedings of the National Academy of Sciences, 1976