EFFECT OF CAPTOPRIL (SQ-14225) ON BLOOD-PRESSURE, PLASMA-RENIN ACTIVITY AND ANGIOTENSIN-I CONVERTING ENZYME-ACTIVITY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 121  (3) , 309-+
Abstract
Patients (7) with essential hypertension and 7 patients with hypertension associated with renal artery stenosis received captopril (SQ 14225), an inhibitor of angiotensin-l converting enzyme. There was a significant reduction in mean blood pressure, from 176/113 .+-. 4/3 mm Hg during the control period to 140/90 .+-. 5/3 mm Hg during captopril administration. Five patients received captopril alone and 9 patients needed hydrochlorothiazide in addition to control their blood pressure. Captopril produced a significant increase in peripheral plasma renin activity. When measured 12 h after the administration of captopril, angiotensin l converting enzyme activity was similar to that during the control period even though the blood pressure was at or near normal. Although captopril is an effective antihypertensive agent, its action does not depend only on inhibition of plasma angiotensin l converting enzyme activity.