Abstract
A large series of barbiturates and other substances have been tested for their ability to prevent motion sickness in dogs. Many compounds were found to possess this activity, which was not related to the anesthetic property of the compound. A number of barbiturates were found to be considerably more active than V-12, which was used as a standard. Pyridoxine, hyoscine, and streptomycin were inactive in the tests described. Bulbocapnine possessed half the potency of V-12 and showed an additive effect when the two substances were given together.

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