Changes in Plasma Renin during Sodium Depletion in Man

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Abstract
Changes in plasma renin were examined on 9 patients without hypertension, 6 with benign essential hypertension and 3 with malignant hypertension before and during dietary salt depletion. In the former 2 groups of patients, renin levels elevated during salt deprivation. On the other hand, in the last group renin showed decrease. It was noted that in the former groups basal renin was within normal range, but in the latter increased. These findings suggest that increase in aldosterone in normal and benign essential hypertension under sodium depletion may be caused by increased renin-angiotensin. Furthermore, it was considered that the basic mechanism of renin secretion in malignant hypertension may be different from that of normotension and benign essential hypertension. Appropriate expalanation of this difference is not yet obtained.