A New Systemic Fungicide Against the Downy Mildew Disease of Cucumbers

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Abstract
Propyl-(3-[dimethylamino]-propyl)carbamate-monohydrochloride (SN66752, propamocarb, a new compound by Schering AG) and prothiocarb (SN41703) exhibited systemic antifungal activity against Pseudoperonospora cubensis, the cause of downy mildew disease of cucumbers [C. sativus]. Aqueous solutions of the chemicals applied as soil drenches to potted cucumbers protected them from the mildew for 25 days. The fungicides were highly toxic to sporangia of the pathogen, induced an alteration in symptoms of the disease, and inhibited sporulation of the fungus on developed lesions.