Isolation of isoguanosine fromCroton tiglium and its antitumor activity
- 1 April 1994
- journal article
- Published by Springer Nature in Archives of Pharmacal Research
- Vol. 17 (2) , 115-118
- https://doi.org/10.1007/bf02974234
Abstract
This paper describes the isolation of isoguanosine fromCroton tiglium L. and its cytotoxic effect against several tumor cell lines in culture and newly reports that isoguanosine has an antitumor activity against implanted S-180 ascitic tumor mice. Isoguanosine is effective at the dose of 24 mg/kg/day×5, with T/C value of 168%. Isoguanosine inhibits the growth of S-180 and Ehrlich solid tumor in mice at the optimal doses of 96 mg/kg/day×12 and 48 mg/kg/day×12, with 1-T/C values of 65% and 60% respectively.Keywords
This publication has 12 references indexed in Scilit:
- Conversion of guanosine into isoguanosine and derivativesJournal of the Chemical Society, Perkin Transactions 1, 1991
- A new synthesis of isoguanosineThe Journal of Organic Chemistry, 1985
- Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysJournal of Immunological Methods, 1983
- Isoguanosine: Isolation from an AnimalScience, 1981
- The determination of 2′-O-methylnucleosides in RNAAnalytical Biochemistry, 1974
- Effect of purine analogues on IMP-pyrophosphorylaseBiochimica et Biophysica Acta (BBA) - Enzymology, 1973
- Accumulation of cyclic adenosine monophosphate in incubated slices of brain tissue. 2. Effects of depolarizing agents, membrane stabilizers, phosphodiesterase inhibitors, and adenosine analogsJournal of Medicinal Chemistry, 1972
- The locus of action of 1-beta-d-arabinofuranosylcytosine in the cell cycle.1969
- THE UTILIZATION OF PURINE NUCLEOSIDES FOR NUCLEIC ACID SYNTHESIS IN THE RATJournal of Biological Chemistry, 1952
- Remarques sur le crotonosideHelvetica Chimica Acta, 1932