Effect of pH on the in vitro potency of clarithromycin against Mycobacterium avium complex
Open Access
- 1 August 1991
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 35 (8) , 1677-1678
- https://doi.org/10.1128/aac.35.8.1677
Abstract
Employing 7H11 agar medium at pH 6.6, the MICs of clarithromycin for 50% (MIC50) and 90% (MIC90) of 19 strains of Mycobacterium avium complex were 8 and 16 micrograms/ml, respectively. However, the MICs were 2 to 3 log2 dilutions lower in the 7H11 medium adjusted to pH 7.4, and the MICs on 10% OADC (oleic acid-albumin-dextrose-catalase)-enriched Mueller-Hinton agar at pH 7.3 were also 2 log2 dilutions lower than those measured on 7H11 agar at pH 6.6. Therefore, clarithromycin is more active at a physiologic than at an acidic pH.Keywords
This publication has 7 references indexed in Scilit:
- Comparative in-vitro activity of twenty antimicrobial agents against clinical isolates of Mycobacterium avium complexJournal of Antimicrobial Chemotherapy, 1989
- In vitro and in vivo activities of clarithromycin against Mycobacterium aviumAntimicrobial Agents and Chemotherapy, 1989
- In vitro activities of several new macrolide antibiotics against Mycobacterium avium complexAntimicrobial Agents and Chemotherapy, 1989
- In vitro activities of azithromycin (CP 62,993), clarithromycin (A-56268; TE-031), erythromycin, roxithromycin, and clindamycinAntimicrobial Agents and Chemotherapy, 1988
- In vitro activity of a new macrolide, A-56268, compared with that of roxithromycin, erythromycin, and clindamycinAntimicrobial Agents and Chemotherapy, 1987
- In vitro and in vivo evaluation of A-56268 (TE-031), a new macrolideAntimicrobial Agents and Chemotherapy, 1986
- Effect of Carbon Dioxide and pH on Susceptibility of Bacteroides fragilis Group to ErythromycinAntimicrobial Agents and Chemotherapy, 1981