Increased Sarcoma Virus RNA in Cells Transformed by Leukemia Viruses: Model for Leukemogenesis
- 11 June 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 192 (4244) , 1143-1145
- https://doi.org/10.1126/science.179144
Abstract
A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes.This publication has 12 references indexed in Scilit:
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