The antidepressant potential of oral S‐adenosyl‐l‐methionine*

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Abstract
S‐adenosyl‐l‐methionine (SAMe), a naturally occurring brain metabolite, has previously been found to be effective and tolerated well in parenteral form as a treatment of major depression. To explore the antidepressant potential of oral SAMe, we conducted an open trial in 20 outpatients with major depression, including those with (n= 9) and without (n= 11) prior history of antidepressant nonresponse. The group as a whole significantly improved with oral SAMe: 7 of 11 non‐treatment‐resistant and 2 of 9 treatment‐resistant patients experienced full antidepressant response. Side effects were mild and transient.