Enzymatic Oxidation and Reduction of C19–Δ5–3β–Hydroxysteroids by Hepatic Microsomes. II. Effect of Age in Rats on 16,17–Oxido—Reduction of 3β–Hydroxyandrost–5–en–17–one (DHA)1

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Abstract
The activities of the DHA 16αhydroxylase, and the 16α– and 17β–hydroxysteroid dehydrogenases of hepatic microsomes of male and female rats have been studied in animals from 20 to 105 days of age. These C–16α–oxidoreductases are sex—linked with a significant accumulation of their products, 16–keto—A5–diol, 16α–0H—DHA and A5–triol appearing in males at puberty and increasing thereafter. The formation of 16–keto—A5–diol predominated over that of 16α– OH—DHA at all ages. In contrast, the formation of A5–diol, reflecting the DHA–17β–hydroxysteroid dehydrogenase activity was neither sex—linked nor increased after puberty in either sex. (Endocrinology92: 1161, 1973)

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