ASPECIFIC INTERACTION OF PROTEINS WITH POLYMER SURFACES

Publisher Website
Google Scholar
Abstract
Membrane filtration is a common step in the purification of biotechnological products. These processes suffer significantly due to adsorption of proteins and concentration polarization, both reducing the efficiency. By considering the origins of interactions between proteins and their environment - namely electrostatic, entropic-hydrophobic, hydrogen bonding and dispersion forces - membrane modifications have been made so as to reduce these interactions. Results demonstrate that this approach does produce better efficiency membranes. The other aspects considered are effects associated with protein-protein interactions. It is demonstrated that optimisation of these for better filtration efficiency is also possible.