Methylmercury: Effect on serum enzymes and humoral antibody
- 1 May 1977
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 2 (5) , 1115-1123
- https://doi.org/10.1080/15287397709529509
Abstract
Dosages of 20 and 10 ppm methylmercury [an environmental contaminant] were toxic to rabbits while 1 ppm did not produce clinical signs or death. Serum alkaline phosphatase levels were elevated in all rabbits exposed to methylmercury. Methylmercury-exposed rabbits challenged to A/PR8 influenza virus had hemagglutination inhibition titers as much as 4 times lower than those of controls. Histopathologic lesions were found in the cerebellum of rabbits that died. The most significant features of this study were that methylmercury chloride suppressed the humoral immune system and resulted in increased serum alkaline phosphatase levels, which may aid in diagnosis when methylmercury poisoning is suspected.This publication has 10 references indexed in Scilit:
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